Professor James Scott
BSc, MSc, MB BS, FRCP, Cbiol, FIBiol, FMedSci, FRS
Professor Scott is a Consultant Physician and Professor of Medicine at Imperial College Healthcare NHS Trust.
Professor Scott FRCP, FRS, is a Consultant Physician and Professor of Medicine at Imperial College Healthcare NHS Trust. He is a specialist of many years of experience, who treats people concerned about their cholesterol level in the blood, have a family member who has suffered a heart attack or stroke, or who need their risk for heart attack or stroke reduced by attention to cholesterol, blood sugar and blood pressure.
Professor Scott is particularly interested in cholesterol metabolism and transport in the blood, cardiovascular disease risk, type 2 diabetes, and the treatment of memory disturbances in early Alzheimer’s disease. Reduction of blood cholesterol levels substantially reduces the risk of atherosclerosis, the cause of heart attacks and strokes even when blood cholesterol levels are already quite low compared to the National average. The management of these risk factors for heart disease and strokes also decreases the risk of Alzheimer’s disease.
He is one of the rare clinical doctors who is a Fellow of the Royal Society (FRS), a fellowship awarded through the Royal Society by The Queen for distinguished service to science.
This award was given for discovering a totally novel mechanism, which affects cholesterol transport in the blood through mutation of the human genome, and which now turns out also to be the most common cause of cancer that there is as a rogue by-product of its normal activity.
This activity is called APOBEC (Apolipoprotein B mRNA editing enzyme complex), after Scott’s original discovery and subsequent discoveries by Scott. He initially discovered that intestinal cholesterol absorption is governed by a totally unique nucleic acid editing mechanism, which changes C to U in the human genome. He then found that a closely related process defends against virus attack by mutating viral genomes thus killing viruses.
As a rogue by-product this defence mechanism attacks the human genome, and through this APOBEC attack this mechanism is now recognised as the most common cause of cancer that there is, more common than UV light or cigarette smoking.
Scott is now developing drugs that block this APOBEC cancer causing mechanism. These discoveries have also led him to be awarded Fellowship of The Royal College of Physicians (FRCP) for distinguished service to medicine as well as fellowship of The Royal Society.
He has special expertise in genetics, genomics, and DNA. His particular clinic skill is lowering blood cholesterol levels in those with high blood cholesterol levels or family history of heart disease or stroke, as well as dealing with statin side-effects. A further skill is treatment of the risk factors that lead to Alzheimer's disease. These are the self-same risk factors that lead to heart disease and stroke.
NHS and academic posts
Consultant Physician and Professor of Medicine at Imperial College Healthcare NHS Trust, and Fellow of the Royal Society.